GenoSolutions offers one osteogenomic test. This test:

• Evaluates polymorphisms that modulate bone formation (collagen synthesis), bone breakdown (resorption), and inflammation, including key regulatory mechanisms affecting calcium and Vitamin D3 metabolism
• Helps identify individuals who may need more than standard bone therapy to prevent osteoporosis
• Uncovers genetic susceptibility to low bone mineral density, osteoporosis, osteopenia, age-related bone fractures, and arthritis

Bone Formation

COL1A1 (collagen 1, alpha-1)
CALCR (calcitonin receptor)
VDR (Vitamin D3 receptor)

These genes affect the synthesis of collagen (the primary fibrous tissue in bone and cartilage), the metabolic actions of the hormones calcitonin and Vitamin D3, the activity of osteoblasts (bone- building cells) and osteoclasts (bone-eroding cells), as well as the regulation of calcium absorption.

Bone Resorption/ Inflammation (Allergy, Asthma, and Atopy)

IL-6 (interleukin-6)
TNF-alpha (tumor necrosis factor-alpha)

These genes influence the regulation and activity of pro-inflammatory cytokines. Variations in genotype are associated with chronic inflammation that may increase bone resorption and risk of osteoporosis.