GenoSolutions offers one inflammation test.

• This profile is a unique genotype-phenotypic assessment that evaluates genomic risk of inflammation, as well as the current expression of the latter
• Uncovers potential genetic susceptibility to chronic inflammation, increased risk of H. Pylori, insulin resistance, increased risk of asthma, atherosclerosis, hypertension, and coronary artery disease
• Includes a phenotypic evaluation of hs C-reactive Protein (CPR), homocysteine and fibrinogen

Interleukin 1-beta (IL-1b):

Health implications include increased production of IL-1b with an increased tendency to chronic inflammation, and decreased production of gastric hydrochloric acid, which may affect protein digestion and increase risk of H. pylori infection Interleukin 6 (IL-6): Health implications for the "wild type" genotype include higher baseline IL-6 levels, insulin resistance, and inflammatory conditions such as osteoporosis and atherosclerosis.

Tumor Necrosis Factor- alpha (TNF-a): alpha (TNF-a): Health implications include increased production of TNF-a, increased inflammatory tendency, increased risk of asthma and atopy, osteoporosis, artherosclerosis, and insulin resistance.

Methylene Tetrahydrofolate Reductase (MTHFR): Health implications include decreased methylation capacity (>50% reduction), and increased risk of elevated homocysteine levels, may alter capacity for neurotransmitter synthesis (serotonin and catecholamines), DNA synthesis, carnitine and Co-Q10 synthesis (energy metabolism), detoxification, and detoxication of heavy metals.

Selectin E (SELE), or endothelial leukocyte adhesion molecule-1, participates in the interaction between leukocytes and the endothelium of blood vessels and is involved in the pathophysiology of atherosclerosis.

Angiotensin 1 (AGT), is a polypeptide hormone that stimulates smooth muscle contraction as well as sodium and water retention, resulting in elevated blood pressure. It is also associated with increased AGT production and consequently with essential hypertension and coronary artery disease.

Phenotypic Evaluation includes:

hs C-Reactive Protein (CRP): Short-term elevations of hs CRP can occur with fever, Inflammation and viral or bacterial infections, so these are important factors to note at the time of sample collection. The hs-CRP reflects inflammatory processes which, if chronic, confer increased risk of cardiovascular and other diseases.

Homocysteine: Elevated homocysteine is a key independent risk factor for cardiovascular disease. Smoking and hypertension increase cardiovascular risks associated with high homocysteine. B-complex vitamins, such as folic acid, B6 and B12 are typically able to decrease homocysteine levels.

Fibrinogen: Fibrinogen is manufactured by the liver and is an important participant in the normal clotting process. Elevated levels of fibrinogen enhance coagulation and increase blood viscosity. Factors such as inflammation, smoking stress, oral contraceptives, aging and obesity may significantly increase fibrinogen levels.