GenoSolutions offers one Immunogenomic test:

• Evaluates polymorphisms that modulate immune and inflammatory activity, affecting immune system defense and resistance to infection
• Evaluates chronic inflammatory mechanisms in asthma, allergy, arthritis, and auto-immune disorders
• Uncovers genetic susceptibility to asthma, auto-immune disorders, certain cancers, bone inflammation, arthritis, H. Pylori (ulcers), heart disease, and osteopenia

Chronic Inflammation

IL-1β (interleukin-1beta)

This gene affects the duration and intensity of the acute inflammatory response. The polymorphism leads to increased stimulation of pro-inflammatory agents such as COX-2 and prostaglandins, reduced ability to shut down inflammatory cascades, and increased susceptibility to H. pylori infection. H. pylori infection has been associated with gastric cancer.

TH-1 Cytokines (Viral Infection & Cancer)

TH-1 Cytokines
TNF-alpha (tumor necrosis factor-alpha)

Polymorphisms of this gene affect cell-mediated immunity, increasing production of the pro-inflammatory cytokine TNF-alpha. This can promote or exacerbate chronic conditions such as arthritis, osteoporosis, and asthma.

TH-2 Cytokines (Allergy, Asthma, and Atopy)

IL-4 (interleukin-4)
IL-4 (interleukin-4)
IL-10 (interleukin-10)
IL-13 (interleukin-13)

TH-2 cytokines promote humoral immunity, including the synthesis of IgE. They are generally regarded as anti-inflammatory; however, excessive activity of some of these cytokines may promote the development of allergic conditions such as atopy, asthma, and hypersensitivity. Low levels may result in chronic inflammatory conditions characterized by a TH-1 response. IL-6 has both pro- and anti-inflammatory properties; this cytokine drives the acute phase response and can promote chronic inflammation and progression in autoimmune disease.