GenoSolutions offers one cardiogenomic test,
the Cardiogenomic Premium Profile.

This test:

• Evaluates polymorphisms that modulate blood pressure, clotting factors, cholesterol balance, lipid balance, nutrient metabolism, inflammation, and oxidative stress
• Uncovers genetic susceptibility to hypercholesteremia, atherosclerosis, obesity, hypertension, coronary artery disease, myocardial infarction, thromboses, endothelial dysfunction, and stroke
• Provides the basis for early nutrient-based prevention of cardiovascular disease

Cholesterol Regulation and Atherosclerosis

ApoE (apoliprotein E)
CETP (cholesteryl ester transfer protein)
SELE (selectin E)

These genes affect how the body breaks down and clears fats and how cholesterol is processed. They also affect lipid balance, plaque formation, and blood vessel integrity and function.

Methylation

MTHFR (C677T   G1298T polymorphisms)

Polymorphisms of this enzyme can disrupt the metabolism of B vitamins (including folate), potentially leading to the build-up of homocysteine. The presence of these SNPs can increase risk of cardiovascular disease, blood vessel damage, thromboses (blood clots), stroke, and degenerative aging.

Hypertension

GNB3 (guanine nucleotide-binding protein)
AGT (angiotensin)
AGTR1 (angiotensin II receptor-1)

Polymorphisms of these genes are associated with blood vessel constriction, sodium and water retention, obesity, and increased susceptibility to hypertension.

Coagulation

Factor 2 (prothrombin)
Factor 5 (Leiden)
PAI-1 (Plasminogen activator inhibitor-1)
GP3a (Glycoprotein 3)

These genetic variants can over-activate blood clotting processes, increasing the risk of sudden cardiac events such as thromboses, heart attacks, and strokes.

Reduction-Oxidation Balance

CYBA*8 (cytochrome b-245-alpha)

This genetic variant mediates the balance between oxidative stress and antioxidant defense in smooth muscle cells lining blood vessels.